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The Denisovans

12 questions · Science

The Denisovans are the first human group described not from their bones but from their DNA. In 2008 Russian researchers found the tip of a little finger, probably a girl's, in Denisova Cave in the Siberian Altai Mountains. The fragment was unremarkable, but the icy cave had preserved its DNA, and when the Leipzig team around Svante Pääbo read it in 2010, it matched nothing known: neither Neanderthal nor modern human, but a third, previously unknown human form that had split from the Neanderthal line hundreds of thousands of years earlier. To this day only a handful of fossils are securely assigned: teeth, finger bones, skull fragments and a jawbone found at 3,300 metres on the Tibetan Plateau. From that jaw comes one of palaeogenetics' finest twists: Denisovan genes explain why people in Tibet cope so well with thin air: the variant of the gene EPAS1 came from them. Elsewhere too they live on: in Melanesia and among Aboriginal Australians, Denisovan ancestry reaches four or five percent, far more than anywhere else. And in the same Siberian cave lay a bone splinter carrying perhaps the most moving news in all of human history: it belonged to a girl whose mother was a Neanderthal and whose father was a Denisovan: the first known first-generation person of mixed human ancestry.

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How were the Denisovans recognised as a distinct human group?

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By their DNA

A single finger bone sufficed: the first human group ever defined not by the shape of bones but by its genome.

In the Altai Mountains of Siberia

Foto: Yuriy59 · CC BY-SA 3.0 · Wikimedia Commons

In which mountain range is the eponymous Denisova Cave?

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In the Altai Mountains of Siberia

The cave was occupied in turn by Denisovans, Neanderthals and modern humans: a unique archive, DNA included, thanks to the cold.

A finger bone

Foto: Thilo Parg · CC BY-SA 3.0 · Wikimedia Commons

Which tiny find yielded the first Denisovan genome in 2010?

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A finger bone

The tip of a little finger, probably a girl's. So unremarkable that nobody would have credited it with a new human group.

Where do people today carry the highest share of Denisovan ancestry?

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In Papua New Guinea and the Philippines

Among Papuans, other Melanesians and Aboriginal Australians, Denisovan ancestry makes up several percent of the genome; in 2021 the Ayta Magbukon of the Philippines turned out to carry even more. Denisovans must therefore have ranged far beyond Siberia.

Which adaptation of today's Tibetans comes from Denisovan genes?

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Tolerance of high altitude

The gene variant EPAS1 stops blood thickening dangerously in thin air. It demonstrably comes from Denisovans: inherited protection that still saves lives.

Where was the first larger Denisovan bone outside Siberia found?

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On the Tibetan Plateau

A jawbone from Baishiya Karst Cave at 3,280 metres, about 160,000 years old: identified not by DNA but by proteins in the tooth enamel.

What was special about the girl "Denny" from Denisova Cave?

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Her mother was a Neanderthal, her father a Denisovan

One bone splinter was enough to prove it: the first known first-generation child of two different human groups. She died at about 13.

Which human group are Denisovans most closely related to?

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The Neanderthals

Both lines separated from each other hundreds of thousands of years ago, after splitting jointly from our own line: sister groups, then.

How many Denisovan fossils are known so far?

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Only a handful

Teeth, finger bones, skull fragments, a jaw, a rib. Almost nothing is known about their appearance: reconstructions rest on chemical signatures in the genome.

How were Denisovans detected in cave layers containing no bones at all?

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Through DNA in the sediment

Genetic material filtered from soil reveals who occupied a cave and when; a method that has been transforming archaeology since 2017.

Where does Denisova Cave get its name?

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From a hermit named Denis

The Russian recluse is said to have lived there in the 18th century. So an entire human group is named after a man who came tens of thousands of years after them.

Since 2025 the Harbin skull counts as Denisovan. Which species name had it been given in 2021?

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Homo longi

Proteins from the bone and mitochondrial DNA from dental calculus linked the more than 146,000-year-old Harbin skull to the Denisovans in 2025. The group thus has its first skull and in Homo longi a name, though the naming is still debated.

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